Design, Synthesis, and Evaluation of Isoxazole-Based Compounds for Exploring Novel Biological Activities and Pharmacokinetic Profiles

Abstract

This study aimed to synthesize and characterize novel isoxazole-based compounds and evaluate their potential biological activities. The objective was to design molecules with specific biological targets in mind, synthesize them using versatile methods, and assess their efficacy, toxicity, and pharmacokinetic properties. The methodology involved strategic design and planning of molecules based on desired biological activities, followed by synthesis using methods such as the Paal-Knorr synthesis for isoxazole ring formation. Subsequent functionalization and characterization techniques validated the synthesized compounds. Biological activity testing assessed efficacy against specific targets, while toxicity evaluations ensured safety. Pharmacokinetic properties provided insights into compound behavior in biological systems. Findings revealed promising outcomes, with the synthesized compounds demonstrating significant efficacy against their respective biological targets. Lower IC50 values indicated higher potency, while manageable cytotoxicity levels and favorable pharmacokinetic properties suggested potential for further development. this study highlights the successful synthesis and characterization of novel isoxazole-based compounds with promising biological activities. These findings contribute to the field of medicinal chemistry, providing insights into structure-activity relationships and laying the groundwork for the development of potential drug candidates. Further optimization and investigation are warranted to fully harness their therapeutic potential.